Publications of the Nestler Laboratory

Books

Nestler, E.J. and Greengard, P. (1984) Protein Phosphorylation in the Nervous System, J. Wiley & Sons, New York.

Hyman, S.E. and Nestler, E.J. (1993) The Molecular Foundations of Psychiatry, American Psychiatric Press, Washington, D.C.

Goldstein, A. and Nestler, E.J. (Eds.) (1998) Special Issue: Neurobiology of Addiction. Drug and Alcohol Dependence, vol. 51, numbers 1 and 2.

Charney, D.S. and Nestler, E.J. (Eds.) (2009) Neurobiology of Mental Illness, 3rd Ed., Oxford University Press, New York. (1st edition published in 1999, 2nd ed. in 2003.)

Nestler, E.J., Hyman, S.E., and Malenka, R.C (2009) Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 2nd Ed., McGraw-Hill, New York. (1st edition published in 2001.)

Rosenberg, R.N., DiMauro, S., Paulson, H.L., Ptacek, L., and Nestler, E.J. (Eds.) (2008) The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 4th Ed, Lippincott, Williams and Wilkins, New York. (3rd edition published in 2003.)

Selected Original Research Articles and Reviews
(>400 total publications)

Nestler, E.J., Hope, B.T., and Widnell, K.L. (1993) Drug addiction: A model for the molecular basis of neural plasticity. Neuron 11:995-1006.

Hope, B.T., Nye, H.E., Kelz, M.B., Self, D.W., Iadarola, M.J., Nakabeppu, Y., Duman, R.S., and Nestler, E.J. (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235-1244.

Self, D.W., Barnhart, W.J., Lehman, D.A., and Nestler, E.J. (1996) Opposite modulation of cocaine-seeking behavior by D1-like and D2-like dopamine receptor agonists. Science 271:1586-1589.

Nestler, E.J. and Aghajanian, G.K. (1997) Molecular and cellular basis of addiction. Science 278:58-63.

Carlezon, W.A., Jr., Boundy, V.A., Haile, C.N., Kalb, R.G., Neve, R., and Nestler, E.J. (1997) Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814.

Carlezon, W.A., Jr., Thome, J., Olson, V.G., Lane-Ladd, S.B., Brodkin, E.S., Hiroi, N., Duman, R.S., Neve, R.L., and Nestler, E.J. (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275.

Kelz, M.B., Chen, J.S., Carlezon, W.A., Whisler, K., Gilden, L., Beckmann, A.M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D.W., Tkatch, R., Baranauskas, G., Surmeier, D.J., Neve, R.L., Duman, R.S., Picciotto, M.R., and Nestler, E.J. (1999) Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 401:272-276.

Nestler, E.J. (2001) Molecular basis of neural plasticity underlying addiction. Nature Rev. Neurosci. 2:119-128.

Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J., and Monteggia, L.M. (2002) Neurobiology of depression. Neuron 34:13-25.

Barrot, M., Olivier, J.D.A., Perrotti, L.I., Impey, S., Storm, D.R,, Neve, R.L., Zachariou, V., & Nestler, E.J. (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA 99:11435-11440.

Rahman, Z., Schwarz, J., Zachariou, V., Gold, S.J., Wein, M., Choi, K.H., et al. (2003) RGS9 modulates dopamine signaling in striatum. Neuron, 38:941-952.

Zachariou, V., Georgescu, D., Sanchez, N., Rahman, Z., DiLeone, R., Berton, O., Simon, M., Neve, R.L., Sim-Selley, L.J., Selley, D.E., Gold, S.J., and Nestler, E.J. (2003) Essential role for RGS9 in opiate action. Proc. Natl. Acad. Sci. USA 100:13656-13661.

McClung, C.A. and Nestler, E.J. (2003) Regulation of gene expression and cocaine reward by CREB and ΔFosB. Nature Neurosci. 11:1208-1215.

Nestler, E.J. and Malenka, R.C. (2004) The addiction brain. Scientific American, March 2004, pp. 78-85.

Monteggia, L.M., Barrot, M., Powell, C.M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R.W., and Nestler, E.J. (2004) Essential role of BDNF in adult hippocampal function. Proc. Natl. Acad. Sci. USA 101:10827-10832.

Barrot, M., Wallace-Black, D., Bolanos, C.A., Graham, D., Perrotti, L.I., Neve, R.L., Chambliss, H., Yin, J.C., and Nestler, E.J. (2005) Regulation of anxiety and initiation of sexual anxiety by CREB in the nucleus accumbens. Proc. Natl. Acad. Sci. USA 102:8357-8362.

McClung, C.A., Sidiropoulou, K., Vitaterna, M., Takahashi, J.S., White, F.J., Cooper, D.C., and Nestler, E.J. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc. Natl. Acad. Sci. USA 102:9377-9381.

Nestler, E.J. (2005) Is there a common molecular pathway for addiction. Nature Neurosci. 8:1445-1449.

Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N.M., Theobald, D.E.H., Truong, H.-T., Russo, S.J., LaPlant, Q., Whistler, K., Neve, R.L., Self, D.W., and Nestler, E.J. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48:303-314.

Zachariou, V., Bolanos, C.A., Selley, D.E., Theobald, D., Cassidy, M.P., Kelz, M.B., Shaw-Lutchmann, T., Berton, O., Sim-Selley, L.J., DiLeone, R.J., Kumar, A., and Nestler, E.J. (2005) ΔFosB: An essential role for ΔFosB in the nucleus accumbens in morphine action. Nature Neurosci. 9:205-211.

Berton, O., McClung, C.A., DiLeone, R.J., Krishnan, V., Russo, S., Graham, D., Tsankova, N.M., Bolanos, C.A., Rios, M., Monteggia, L.M., Self, D.W., and Nestler, E.J. (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868.

Berton, O. and Nestler, E.J. (2005) New approaches to antidepressant drug discovery: Beyond monoamines. Nature Rev. Neurosci. 7:137-151.

Dong, Y., Green, T., Saal, D., Marie, H., Neve, R., Nestler, E.J., and Malenka, R.C. (2006) CREB modulates excitability of nucleus accumbens neuron. Nature Neurosci. 9:475-477.

Tsankova, N.M., Berton, O., Renthal, W., Kumar, A., Neve, R.L., and Nestler, E.J. (2006) Sustained chromatin regulation in hippocampus in a mouse model of depression and antidepressant action: A novel role for HDAC5. Nature Neurosci. 9:519-525.

Russo, S.J., Bolanos, C.A., Theobald, D.E., DeCarolis, N.A., Renthal, W.R., Kumar, A., Winstanley, C.A., Renthal, N.E., Wiley, M.D., Self, D.W., Russell, D.S., Neve, R.L., Eisch, A.J., and Nestler, E.J. (2007) The IRS2-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates. Nature Neurosci. 10:93-99.

Tsankova, N., Renthal, W., Kumar, A., and Nestler, E.J. (2007) Epigenetic regulation in psychiatric disorders. Nature Rev. Neurosci. 8:355-367.

Berton, O., Covington, H.E., Ebner, K., Tsankova, N.M., Carle, T.L., Ulery, P., Bhonsle, A., Barrot, M., Krishnan, V., Singewald, G.M., Singewald, N., Birnbaum, S., Neve, R.L., and Nestler, E.J. (2006) Induction of ΔFosB in the periaqueductal gray by stress promotes active coping responses. Neuron 55:289-300.

Krishnan, V., Han, M.-H., Graham, D.L., Berton, O., Renthal, W., Russo, S.J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D.C., Ghose, S., Reister, R., Tannous, P., Green, T.A., Neve, R.L., Chakravarty, S., Kumar, A., Eisch, A.J., Self, D.W., Lee, F.S., Tamminga, C.A., Cooper, D.C., Gershenfeld, H.K., and Nestler, E.J. (2007) Susceptibility and resistance to social defeat are mediated through molecular adaptations in brain reward regions. Cell 131:391-404.

Renthal, W., Maze, I., Krishnan, V., Covington, H.E., Xiao, G.H., Kumar, A., Russo, S.J., Graham, A., Tsankova, N., Kerstetter, K.A., Kippin, T.E., Neve, R.L., Haggarty, S.J., McKinsey, T.A., Bassel-Duby, R., Olson, E.N., and Nestler, E.J. (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56:517-529.

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S.A., Anderson, J.G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J.K., Nestler, E.J., and Zigman, J.M. (2008) The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nature Neurosci. 11:752-753.

Pulipparacharuvil, S., Renthal, W., Hale, C.F., Taniguchi, M., Xiao, G.H., Kumar, A., Russo, S.J., Sikder, D., Dewey, C.M., Davis, M.M., Greengard, P., Nairn, A.C., Nestler, E.J., and Cowan, C.W. (2008) Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59:621-633.

Krishnan, V. and Nestler, E.J. (2008) The molecular neurobiology of depression. Nature 455:894-902.

Wallace, D.L., Han, M.H., Graham, D.L., Green, T.A., Vialou, V., Iniguez, S.D., Cao, J.L., Chakravarty, S., Kumar, A., Krishnan, V., Neve, R.L., Cooper, D.C., Bolaños, C.A., Barrot, M., McClung, C.A., and Nestler, E.J. (2009) CREB Regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nature Neurosci. 12:200-209.

Renthal, W., Kumar, A., Xiao, G.H., Wilkinson, M., Convington, H.E. III, Mze, I., Sikder, D., Robison, A.J., LaPlant, Q., Dietz, D.M., Russo, S.J., Vialou, V., Chakravarty, S., Kodadek, T.J., Stack, A., Kabbaj, M., and Nestler, E.J. (2009) Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins. Neuron 62:335-348.

Feder, A., Nestler, E.J., and Charney, D.S. (2009) Psychobiology and molecular genetics of resilience. Nature Rev. Neurosci. 10:446-457.